The impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models.
It has been hypothesized that the virulence of lab-passaged Mycobacterium Stove Temperature Sensor tuberculosis and recombinant M.tuberculosis mutants might be reduced due to multiple in vitro passages, and that virulence might be augmented by passage of these strains through mice before quantitative virulence testing in the mouse or guinea pig aer